KEEP CALM & RELISSA™
SLEEP WELL AND LIVE BETTER
Browse all Indena’s documents about products, events, company information and so much more.
Go to section
NUTRACEUTICALS
Relissa™
Melissa Indena Phytosome®
Scroll to see more
FOCUS ON BRAIN HEALTH
FEED YOUR MIND,
FILL YOUR LIFE
Relax during the day and rest well at night, aided by our standardized, non-melatonin lemon balm extract: Relissa™ combines the power of a traditional remedy with the cutting-edge technology of the Indena Phytosome™ delivery platform, for optimal biological performance.
Specifically contrast negative thoughts, anxiety, and stress symptoms, and improve your mental well-being, sleep quality and overall quality of life.
Part of our golden quartet of botanical, food-grade supplements for brain health, verified to support and maintain specific functions with a non-invasive, natural, holistic approach.
Relissa™ wins at the 2024 Nutraingredients Awards!
We’re thrilled to announce that Relissa™ has won the 2024 NutraIngredients Award in the Cognitive Function category!
The prestigious awards organized by NutraIngredients.com celebrate the finest achievements in the nutrition and dietary supplements industry, honoring excellence in ingredients, finished products, companies, individuals, and initiatives.
Winning this accolade is a testament to our commitment to excellence in the field.
BEHIND THE POWER OF REST PURITY AND SCIENTIFIC VALIDATION
With its botanical balance, RelissaTM is scientifically proven to contribute to beneficial effects on mental and sleep health in adults with mild sleep problems associated with depression, anxiety, and stress.1
Melissa leaves are a traditional sleep aid. While over 50 compounds have been identified in lemon balm extracts, today we know that their biological activity is mostly due to hydroxycinnamic and rosmarinic acids and derivatives.2,3
The bright minds at Indena, therefore, focused on achieving the perfect quantification and formulation of these two chemicals, making RelissaTM a standardized, non-melatonin reliable ingredient to ease sleeping difficulties and related symptoms, for better quality of life.
OVERVIEW
We’ve set the absolute advantage
Melissa officinalis leaves are the starting point of the process, as they provide compounds responsible for several beneficial effects, including the promotion of sleep, relaxation, and calm.3,4,5,6,7
But Relissa™ is unlike any other melissa extract: it stands out for its high content of hydroxycinnamic and rosmarinic acid, quantified and standardized for better and effective results, and delivered thanks to the innovative Indena Phytosome™ technology.2
Relissa™ into action
Melissa officinalis has been known for centuries and used for various applications thanks to its calming and “antistress” action, promoting sleep and relaxation. Other widely investigated effects of this botanical include antioxidant and spasmolytic activity, neuroprotection, and anxiolytic action.3,4,5,6,7
Beneficial effects on sleep and mental wellness have been proven on adults after 3 weeks of Relissa™ supplementation in a double-blind randomized clinical study.
In addition, a specific potential interaction was closely analyzed to dispel any concern within the context of recent increased interest in how the microbiome may influence our wellbeing, especially in the realm of mood and sleep.
Lactobacillus rhamnosus – a type of bacteria that is able to colonize the human gastrointestinal tract – has been proven able to improve night rest and rapid eye movement (REM) sleep8, thanks to a positive influence over short-chain fatty acids (SCFAs) controlling the expression of genes responsible for sleep-wake rhythms.9 Relissa™ has shown no negative interactions with Lactobacillus rhamnosus, thus safeguarding its beneficial effect.10
Find out how Relissa™
is one step beyond
Relissa™ is formulated with Indena Phytosome® strategy allowing a better dispersion in gastrointestinal fluids and enhancing the ingredient’s bioaccessibility profile. Indena Phytosome® technology platform grants the beneficial compounds contained in Melissa officinalis offer better biological performances, while still fully respecting their natural profile.2
Leveraging the same technology, Relissa™ can also be provided in the form of gummies; in addition, thanks to its proven effectiveness even at lower daily doses, it can be included in a wide variety of other solutions in the supplement market.
THINGS TO WATCH
Things to watch
Brain Health
Feed your mind, fill your life.
Your brain makes you uniquely you. As life's pace challenges our mental well-being, nature offers specific solution. Discover Indena's golden quartet of botanical ingredients, carefully selected to nurture your brain health and help you live life to its fullest.
HEALTH STORIES / 16 Dec 24
6.23
Relissa™’s sustainable journey
Relissa™ is a new ingredient by Indena, yet reflects all of the company’s milestones and solid values: 100 years of scientific background, innovative formulation solutions and attention to botanical sources.
Indeed, the whole process, starting from Melissa officinalis not only complies with Indena’s high standards, but is also part of a sustainable journey that keeps a careful eye on carbon footprint. The goal is to always select the most virtuous and organic farms and suppliers based in Europe, which can guarantee high quality and environmental awareness at the same time.
These elements translate in a production cycle that has evolved along a virtuous and eco-sustainable path, using driers powered by renewable energy, leveraging waste-heat from systems that run on biogases generated from the fermentation of agro-industrial by-products, and feeding back leftover biomasses into the growing phase, as a soil conditioner.
See through science
Peer-reviewed science on Relissa™
Here you can find more scientific evidence for your review.
ACCESS NOWBibliography
1. Bano A, et al. (2023) Front. Pharmacol. 14:1250560. doi: 10.3389/fphar.2023.1250560.
2. Indena internal data.
3. Shakeri F. et al., Journal of ethnopharmacology 188 (2016): 204-228.
4. Świąder J., Appl. Bot. Food Qual 92 (2019): 327-335.
5. European Commission Monograph – Melissa officinalis.
6. ESCOP – Melissa officinalis.
7. WHO Monograph – Folium Melissae.
8. Thompson R.S. et al., Front Behav Neurosci 2017.
9. Dalile B. et al., Nat Rev Gastroenterol Hepatol 2019.
10. Indena internal data.
Relissa™ AT A GLANCE
Why choose Relissa™?
01.
Supported by a double-blind randomized human study, which confirmed its positive effects on sleeping and mental health.
02.
Perfect for combination products thanks to its effectiveness even at low daily dosages.
03.
Contains a high and standardized concentration of hydroxycinnamic and rosmarinic acids.
04.
Improves and optimizes the distribution in gastrointestinal fluids and absorption profile thanks to Indena Phytosome™ delivery system.
05.
Shows recognized activity promoting healthy sleep and relaxation.
06.
Shows no interaction with Lactobacillus rhamnosus – a bacteria able to colonize the gastrointestinal tract, proven able to improve night rest and rapid eye movement (REM) sleep.
07.
Made with plants of European origin.
08.
Part of Indena’s commitment to maximize sustainability and minimize environmental footprint.
09.
Subject of ESCOP, WHO and EMA monographs.
10.
Can also be formulated in gummies, an increasingly popular solution on the market.
Technical data
Common Name
Melissa phospholipids
Botanical Origin
Melissa officinalis L.
Type
Extract
Plant source
Leaves
Health benefit
Calming action, Healthy sleep, Relaxation
Patent & Trademark
Relissa is a trademark of Indena S.p.A. The use of Indena’s trademarks is subject to Indena’s authorization and to the acceptance of the terms and conditions set out in the Trademark Usage Guidelines downloadable HERE.
Specifications
Optimized bioabsorption profile.
Recommended dose and use
200 mg x 2.
Relissa™ may be used in a variety of supplement formulations.
Assay
17-23% of lemon balm by HPLC
Broad category
Healthy Sleep, Calm & Relaxation
Relissa™ documents
