PURIFICATION, THE SOURCE OF HEALTH
Browse all Indena’s documents about products, events, company information and so much more.
Go to section
NUTRACEUTICALS
PureBKale™
Black kale seed extract
Scroll to see more
Overview
We’ve set the absolute advantage
Kale (Brassica oleracea L. var. acephala, also known as Brassica oleracea var. virids) – a green leafy plant that has been cultivated as a food crop since 2000 BC1 – is a prominent member of the Brassicaceae botanical family, which has been gaining popularity for its widely studied health benefits.
But did you know that kale’s seeds, in addition to its leaves, are packed with molecules that offer precious nutrients to our body? In particular, black kale seeds are a valuable source of glucoraphanin, a compound that the myrosinase activity – by specific bacteria of our gut microbiota – metabolizes into sulforaphane (SFN). SFN is an active isothiocyanate with powerful antioxidant properties, which plays a key role in the detoxification and protection of numerous organs, including the skin and the liver.2
That’s why we’ve developed PureBKale™: an innovative nutraceutical based on an aqueous dry extract exlusively from 100% italian Tuscan black kale seeds, which guarantees high levels of glucoraphanin (≥17%) to maximize SFN’s significant beneficial effect to support of the body’s detoxification and purification processes.
PureBKale™ into action
Both in vitro and in vivo studies have explored SFN’s multi-faceted approach to detoxifying the body. It can effectively interact with the Keap1-Nrf2-ARE signaling pathway and suppress the inflammatory regulator NF-κB; these actions result in a series of antioxidant and anti-inflammatory events: a decrease in the production of inflammatory cytokines, an increase in the activity of antioxidant phase-II enzymes, and the prevention of cell damage and death due to oxidative stress products such as acetaldehyde from alcohol.2,3,4
This detoxifying activity means SFN plays an important role in protecting the skin and improving its natural aging process. In particular, this compound can induce the expression of NQO1, an enzyme that prevents the generation of reactive oxygen species triggered by UV radiation, thus lowering the chances of sunburn and aiding in the prevention of skin cancer.5
The liver is another organ in which SFN’s effects have been extensively researched. Through modulation of the Nrf2 and FGF21 signaling pathways, SFN can inhibit fat buildup (lipogenesis) and oxidative stress, and instead promote anti-inflammatory processes and enhanced breakdown of fatty acids, improving liver metabolism.6
Find out how PureBKale™ is one step beyond
The distinguishing feature of PureBKale™ as a nutraceutical lies in the excellent quality of its core primary ingredient. Right from the start, Indena® conducted a thorough screening of over 20 seed samples from different varieties of kale, to identify Brassica oleracea L. var. acephala as the best ally for detoxification.
This effort has allowed the development of an extract with a significantly high concentration of the SFN precursor glucoraphanin, standardized at a minimum concentration of 17%, achieved without the use of solvents.
Indena® also takes pride in PureBKale™’s all-Italian Tuscan black kale seed supply chain, working in harmony with local communities to ensure an environmentally friendly production process.
Bibliography
1Satheesh N, et al. Cogent Food & Agriculture. 6(1). (2020)
2Cascajosa-Lira A, et al. Phytomedicine: international journal of phytotherapy and phytopharmacology. 130(155731). (2024)
3Petkovic M, et al. The Journal of nutritional biochemistry. 98: 108817. (2021)
4Ushida Y, et al. Alcohol and alcoholism. 48(5): 526-534. (2013)
5Moskwa J, et al. Nutrients. 15(16): 3594. (2023)
6Yan L, et al. Frontiers in pharmacology. 14: 1256029. (2023)
PUREBKALE™ AT A GLANCE
Why choose PureBKale™?
01.
Is a premium food-grade ingredient.
02.
Standardized by HPLC, containing a uniquely high concentration (≥17%) of glucoraphanin, precursor of SFN.
03.
In vitro and in vivo studies have shown SFN to have significant antioxidant and anti-inflammatory characteristics.
04.
SFN plays an important role in preventing skin aging and UV radiation damage.
05.
Antioxidant and lipid metabolism properties of SFN help protect the liver from disease and injury.
06.
SFN has been found to be safe and well tolerated.
07.
Environmentally friendly, local production process of the black kale seed ingredient.
Technical data
Common Name
Tuscan black kale seed extract
Botanical Origin
Brassica oleracea var. virids (L.) (syn. Brassica oleracea var. acephala DC.)
Type
Extract
Plant source
Seed
HALAL Certified
Health benefit
Liver health, Skin Health
Patent & Trademark
PureBKale is a trademark of Indena S.p.A. The use of Indena’s trademarks is subject to Indena’s authorization.
Specifications
PureBKale™ is standardized to contain ≥17% of glucoraphanin by HPLC.
Recommended dose and use
150 mg/day, providing 25 mg/day of sulforaphane glucosinolate. PureBKale™ is a dark brown powder for use in nutritional supplements.
Assay
≥17% of glucoraphanin by HPLC
Broad category
Beauty from within
These statements may not comply with your country’s laws and regulations or with Reg. EC n. 1924/2006 and have not been evaluated by the Food and Drug Administration. The products are not intended to diagnose, treat, cure or prevent any disease. Marketers of finished products containing this ingredient are responsible for ensuring compliance with the applicable legal framework.
PUREBKALE™ DOCUMENTS
