SUPPORT ACHE RELIEF IN A NATURAL WAY
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NUTRACEUTICALS
Acmelain™
Acmella extract
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Overview
We’ve set the absolute advantage
Acmella (Acmella oleracea L.), also known as the “toothache plant” in some cultures, is a botanical species that has been used for centuries to treat oral pain thanks to its analgesic properties. From a phytochemical point of view, its leaves and flowers (aerial part) are rich in bioactive compounds, especially alkylamides. Studies have shown that the most important one among these is spilanthol, because it promotes local anesthetic action as well as many other biological activities, leading to analgesic, antinociceptive, antioxidant and anti-inflammatory benefits.1
Acmelain™ transforms the natural potential of this raw material into a functional ingredient, to guarantee the maximum possible performance thanks to the standardization of total alkylamides (2.5-3.5%) and the use of a custom delivery system based on α- cyclodextrins.
That’s why it can be a reliable ally to maintain reasonable levels of well-being in conditions where chronic pain may occur, helping to tackle a pandemic issue affecting nearly 20% of the global population.2
Acmelain™ into action
Acmella’s mode of action is complex and based on the integration of different mechanisms. In vitro studies by Indena have pointed out that this extraordinary plant has a double effect on ache relief support: a direct one, due to the interaction with cannabinoid receptor CB2, and an indirect one, through the inhibition of the FAAH enzyme, involved in physiological ache relief processes.3
One more point in favor of Acmelain™ is that it can be a reliable team player: preclinical in vivo studies have proved that, when used in combination with Boswellia serrata extract, it exerts a significant synergistic action counteracting neuropathic pain symptoms.4 Moreover, clinical evidence has demonstrated that when administered with Zingiber officinalis formulations (such as Indena’s Mitidol®), it can contrast discomfort in individuals with knee osteoarthritis.5
Finally, recent results have shown that when patients under medical cannabis treatment are supplemented with a combination of coenzyme Q10 (such as Ubiqsome® - Coenzyme Q10 Indena Phytosome®), ginger extract and acmella extract, they report a significant beneficial effect.6
Find out how Acmelain™ is one step beyond
Indena’s commitment towards ensuring the utmost quality of the raw materials it uses begins in the fields. The acmella plants used for Acmelain™ grow in an ideal environment, on land directly owned and managed by the company in Sardinia, Italy; this allows Indena to maximize botanical potential, avoid the use of pesticide, and maintain complete control over the supply chain.
In line with its longtime dedication to excellence, Indena has also studied a custom delivery system to optimize the performance of natural ingredients. For Acmelain™, α-cyclodextrins have been identified as the best way to improve stability, solubility and formulability of acmella’s precious active substances, allowing for maximum health benefits.
See through science
Peer-reviewed science on Acmelain™
Here you can find more scientific evidence for your review.
DISCOVER MOREBibliography
1Rondanelli M. et al., Fitoterapia, 140 104419 (2020).
2Yong R. et al., PAIN, 163 (2) pe328-e332 (2022).
3Petrangolini G. et al., J Nutr Food Sci, 10:766 (2023).
4Boccella S. et al., Phytotherapy research, 1:4 (2023).
5Rondanelli M. et al., Journal of Pain Research, 13:761 (2020).
6Poli P. et al., Evidence-based complementary and alternative Medicine, (2022).
Acmelain™ at a glance
Why choose Acmelain™?
01.
Is a standardized acmella extract with a unique α-cyclodextrin formulation.
02.
Works on the endocannabinoid system, based on a double mechanism of action.
03.
Naturally supports well-being in people suffering from pain-related discomforts.
04.
Can boost the efficacy of other natural ingredients, in combined formulations.
05.
Shows synergic action when mixed with Boswellia serrata extract.
06.
Supported by in vitro and human studies.
07.
Is a fine powder that can be flexibly used in several formulative options.
08.
Comes from a unique, dedicated plantation in Sardinia, Italy.
Technical Data
Common Name
Acmella standardized extract
Botanical Origin
Acmella oleracea (L) R.K. Jensen
Type
Extract
Plant source
Flowers and leaves (aerial part)
Health benefit
Natural support to ache management
Patent & Trademark
Acmelain is a trademark of Indena S.p.A. The use of Indena’s trademarks is subject to Indena’s authorization and to the acceptance of the terms and conditions set out in the Trademark Usage Guidelines downloadable HERE.
Specifications
Acmelain™ is standardized to contain 2.5 - 3.5% of total alkylamides.
Assay
1.9-2.4% Acmella oleracea st. extract (0.30-0.60% spilanthol by HPLC)
Broad category
Support to ache relief
These statements may not comply with your country’s laws and regulations or with Reg. EC n. 1924/2006 and have not been evaluated by the Food and Drug Administration. The products are not intended to diagnose, treat, cure or prevent any disease. Marketers of finished products containing this ingredient are responsible for ensuring compliance with the applicable legal framework.
