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Relissa™
Relissa™

NUTRACEUTICALS

Relissa™

Melissa Indena Phytosome™

KEEP CALM & RELISSA
SLEEP WELL AND LIVE BETTER

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FOCUS ON BRAIN HEALTH

Relissa™ for Brain Health

Relax during the day and rest well at night, aided by our standardized, non-melatonin lemon balm extract: Relissa™ combines the power of a traditional remedy with the technology of Indena Phytosome™ delivery platform, for optimal biological performance.
Specifically contrast negative thoughts, anxiety, and stress symptoms, and improve your mental well-being, sleep quality and overall quality of life.

explore the results

Relissa™ wins at the 2024 Nutraingredients Awards!

We’re thrilled to announce that Relissa™ has won the 2024 NutraIngredients Award in the Cognitive Function category!

The prestigious awards organized by NutraIngredients.com celebrate the finest achievements in the nutrition and dietary supplements industry, honoring excellence in ingredients, finished products, companies, individuals, and initiatives.

Winning this accolade is a testament to our commitment to excellence in the field.

Relissa™ wins at the 2024 Nutraingredients Awards!

BEHIND THE POWER OF REST PURITY AND
SCIENTIFIC VALIDATION

With its botanical balance and multiple scientific confirmations, RelissaTM is scientifically proven to contribute to beneficial effects on mental balance and on sleep health in adults with mild sleep problems, also associated with bad mood, anxiety, and stress.1,2

Melissa leaves are a traditional sleep aid. While over 50 compounds have been identified in lemon balm extracts, today we know that their biological activity is mostly due to hydroxycinnamic and rosmarinic acids and derivatives.3,4

The bright minds at Indena, therefore, focused on achieving the perfect quantification and formulation of these phytoactives, making RelissaTM a standardized, non-melatonin reliable ingredient to support healthy sleeping, and ease mood for better quality of life around the clock.

image-large-relissa-new

OVERVIEW

We’ve set the absolute advantage

Melissa officinalis has been known for centuries and used for various applications thanks to its calming and “antistress” action, promoting sleep and relaxation. Other widely investigated effects of this botanical include antioxidant and spasmolytic activity, neuroprotection, and anxiolytic action.3,4,5,6,7

Nowadays the market offers a plethora of lemon balm-based solutions, which in most cases are sacrificing quality, transparecy and then science itself: unknown phytochemical profile, erratic dosages, absence of human studies hamper traditional melissa extract from delivering any benefit.8

But Relissa™ is unlike any other melissa extract: it stands out for its quantified and standardized content of hydroxycinnamic and rosmarinic acid, delivering effective results thanks to the innovative Indena Phytosome™ technology.1,2

We’ve set the absolute advantage

Relissa™ into action

Beneficial effects on sleep and mental wellness linked to bad mood, anxiety and stress have been proven on adults after 3 weeks of Relissa™ supplementation in a double-blind, placebo controlled randomized clinical study, lasting up to 24 hrs.1

In a recent new placebo controlled human study, Relissa™ has been validated as sleep aid, reliving from insomnia symptoms increasing the time spent in deep sleep thus improving overall sleep quality, positively affecting the cognitive performance during the day.2 As smartwatches become increasingly widespread and commonly worn, Relissa's beneficial effects can now be experienced "first hand" on a personal level. This accessibility allows users to monitor and appreciate its positive impact directly through wearable devices.

Relissa™’s clinical efficacy is supported by its unique mechanism of action, including superior antioxidant and neuroprotective effects and GABA-t enzyme inhibiting property compared to traditional unformulated melissa extracts. These results are enhanced by proprietary Indena Phytosome® technology, optimizing performances and effectiveness.11

In addition, a specific potential interaction was closely analysed to dispel any concern within the context of recent increased interest in how the microbiome may influence our wellbeing, especially in the realm of mood and sleep.
Lactobacillus rhamnosus – a type of bacteria that is able to colonise the human gastrointestinal tract – has been proven able to improve night rest.8 Relissa™ has shown no negative interactions with Lactobacillus rhamnosus, thus safeguarding its beneficial effects.10

Relissa™ into action

Find out how Relissa™
is one step beyond

Relissa™ is formulated with Indena Phytosome™ strategy allowing a better dispersion in gastrointestinal fluids and enhancing the ingredient’s bioaccessibility profile. Indena Phytosome™ technology platform grants the beneficial compounds contained in Melissa officinalis offer better biological performances, while still fully respecting their natural profile.2

Leveraging the same technology, Relissa™ can also be provided in the form of gummies; in addition, thanks to its proven effectiveness even at lower daily doses, it can be included in a wide variety of other solutions in the supplement market.

Find out more on Indena Phytosome™

Things to Watch

Things to watch

Brain Health
Feed your mind, fill your life.

Your brain makes you uniquely you. As life's pace challenges our mental well-being, nature offers specific solution. Discover Indena's golden quartet of botanical ingredients, carefully selected to nurture your brain health and help you live life to its fullest.

HEALTH STORIES / 20 Mar 25
6.23
Brain Health <br /><strong><em>Feed your mind, fill your life.</em></strong>
Go to detail

Relissa™’s sustainable journey

Relissa™ is a new ingredient by Indena, yet reflects all of the company’s milestones and solid values: 100 years of scientific background, innovative formulation solutions and attention to botanical sources.

Indeed, the whole process, starting from Melissa officinalis not only complies with Indena’s high standards, but is also part of a sustainable journey that keeps a careful eye on carbon footprint. The goal is to always select the most virtuous and organic farms and suppliers based in Europe, which can guarantee high quality and environmental awareness at the same time.

These elements translate in a production cycle that has evolved along a virtuous and eco-sustainable path, using driers powered by renewable energy, leveraging waste-heat from systems that run on biogases generated from the fermentation of agro-industrial by-products, and feeding back leftover biomasses into the growing phase, as a soil conditioner.

See through science

Bibliography
1. Bano A, et al. (2023) Front. Pharmacol. 14:1250560. doi: 10.3389/fphar.2023.1250560.
2. Di Pierro F., et al. Nutrients 16.23 (2024): 4199.
3. Indena internal data.
4. Shakeri F., et al., Journal of ethnopharmacology 188 (2016): 204-228.
5. European Commission Monograph – Melissa officinalis.
6. ESCOP – Melissa officinalis.
7. WHO Monograph – Folium Melissae.
8. Świąder J., Appl. Bot. Food Qual 92 (2019): 327-335.
9. Kara M., et al. (2024) Frontiers in Molecular Biosciences 11: 1359177 
10. Thompson R.S. et al., Front Behav Neurosci 2017.
11. Indena internal data.

 

 

Relissa™ AT A GLANCE

Why choose Relissa™?

01.

Supported by double-blind randomized human studies, which confirmed its positive effects on sleeping and mental health.

02.

Double standardization in hydroxycinnamic and rosmarinic acids

03.

Improves and optimizes the dispersion in gastrointestinal fluids and performances thanks to Indena Phytosome™ delivery system.

04.

Shows no interaction with Lactobacillus rhamnosus – a bacteria able to colonize the gastrointestinal tract, proven able to improve night rest and rapid eye movement (REM) sleep.

05.

More effective than traditional unformulated lemon balm extract as antioxidant, neuroprotective agent and GABA-t enzyme inhibitor in preclinical test.

06.

Made with plants of European origin. Part of Indena’s commitment to maximize sustainability and minimize environmental footprint.

07,

Can also be formulated in smart dosage forms including gummies, an increasingly popular solution on the market.

08.

Perfect for combination products thanks to its effectiveness even at low daily dosages.

Technical data

Common Name

Melissa phospholipids

Botanical Origin

Melissa officinalis L.

Type

Extract

Plant source

Leaves

Health benefit

Healthy sleep, Relaxation

Patent & Trademark

Relissa is a trademark of Indena S.p.A. The use of Indena’s trademarks is subject to Indena’s authorization.

Specifications

Optimized bioabsorption profile.

Recommended dose and use

200 mg x 2.
Relissa™ may be used in a variety of supplement formulations.

Assay

17-23% of lemon balm by HPLC

Broad category

Chonic ache relief, Beauty from within, Weight loss companion

Relissa™ documents

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