Joining forces to help ease aches
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NUTRACEUTICALS
Mitidol®
Standardized combination of ginger & acmella oleracea
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Overview
We’ve set the absolute advantage
Ginger (Zingiber officinale Roscoe) is an excellent source of several bioactive phenolics, including non-volatile pungent compounds (gingerols, paradols, shogaols and zingerones) whose major properties embrace immune modulatory, anti-inflammatory, anti-tumorigenic, anti-hyperglycemic and antilipidemic actions.1
Acmella (Acmella oleracea L.) has been used for centuries to treat oral pain because of its analgesic properties. Studies has shown that Spilanthol is the principal compound that promotes local anesthetic action and has many other biological activities such as analgesic, antinociceptive, antioxidant, anti-inflammatory and anti-wrinkle.2
Born from the smart combination of these 2 standardized extracts and exploiting the synergy of this amazing couple, Mitidol® is an innovative natural solution which have been developed to provide an effective ache management support.
Mitidol® into action
Two recent in vitro experiments has clarified Ginger and Acmella mechanism of action, proving that their combination in the Mitidol® formulation has a double effect on ache relief support: a direct one thanks to the interaction with the cannabinoid receptor CB2 and an indirect one through the inhibition of FAAH enzyme, involved in the physiological ache relief processes.3
Moreover, the powerful combination of the 2 extracts support knee functionality and comfort, according to a one-month human trial conducted on 50 subjects with knee challenge.4
Find out how Mitidol®
is one step beyond
Starting from the commitment toward the choice of the best raw materials (Sardinia proprietary cultivation to optimize the quality of the Acmella biomass), toward the use of technological formulative solutions (the blend of 2 oily liquid extract transformed in a unique fine-powder ingredient), Mitidol® is the result of Indena’s scientific expertise in the field of ache management support.
Things to watch
Things to watch
Mitidol®
Joining forces to help ease aches
The power of Zingiber together with the power of Acmella can only mean one thing: one step ahead in pain management. Discover Mitidol®, the amazing combination of these 2 botanical derivatives, powered by Indena.
PRODUCTS / 24 Jun 24
3.53
See through science
Peer-reviewed science on Mitidol®
Here you can find more scientific evidence for your review.
ACCESS NOWBibliography
1Srinivasan K. et al., Pharma Nutrition 5, 18–28 (2017).
2Rondanelli M. et al, Fitoterapia, 140, 104419 (2020).
3Petragolini G. et al., Journal of Nutrition & Food Sciences Vol 10, 1 (2020).
4Rondanelli M et al. Manuscript accepted for publication.
Mitidol® at a glance
Why choose Mitidol®?
01.
Is a smart combination of Acmella oleracea and Zingiber officinale plants working together in a powerful way: as reported by literature data, both plants can be useful as ache modulators.
02.
Is supported by a human efficacy study and 2in vitro mechanistic studies.3,4
03.
Is active on the endocannabinoid system (CB2 and FAAH in vitro models).3
04.
Contributes to relief from knee challenges.4
05.
Optimizes knee function (confirmed with WOMAC and Lhysolm scale).4
06.
Is a fine powder perfect for solid dosage forms.
Technical Data
Common Name
Acmella and Zingiber standardized extracts
Botanical Origin
Acmella oleracea (I) R.K. Jensen / Aerial part Zingiber officinale Roscoe
Type
Extract
Plant source
Rhizome (Zingiber), Aerial part (Acmella)
Health benefit
Natural ache relief
Patent & Trademark
Mitidol is patented (EP3554523).
Mitidol is a trademark of Indena S.p.A The use of Indena’s trademarks is subject Indena’s authorization and to the acceptance of the terms and conditions set out in the Trademark Usage Guidelines downloadable HERE.
Specifications
350 mg twice a day. Mitidol® is a yellowish fine powder with good technological properties (e.g. density, flowability), easy to formulate and mainly suitable for capsules and tablets.
Recommended dose and use
A combination of ginger and acmella with innovative formulation which blends the 2 oily liquid extracts in a unique fine-powder ingredient.
Assay
9.6-11.8% Zingiber officinale CO2 extract (2.4-3.9% total gingerols and shogaols by HPLC); 1.9-2.4% Acmella oleracea st. extract (0.30-0.60% spilanthol by HPLC)
Broad category
Ache management
These statements may not comply with your country’s laws and regulations or with Reg. EC n. 1924/2006 and have not been evaluated by the Food and Drug Administration. The products are not intended to diagnose, treat, cure or prevent any disease. Marketers of finished products containing this ingredient are responsible for ensuring compliance with the applicable legal framework.
Mitidol® documents
News about Mitidol®
NEWS / 15 Dec 20
Ginger and Acmella, together in Mitidol®: a smart couple for effective ache relief support
Indena has been focusing for years in developing a supportive ingredient to face one of the most relevant global health issues: ache management. The result is Mitidol®, an amazing combination of 2 botanicals working together very effectively: ginger and acmella.
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