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NUTRACEUTICALS
Cronilief™
PEA - Indena Phytosome™
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Overview
We’ve set the absolute advantage
Discovered in the 1950s, palmitoylethanolamide (PEA) is the N-acylethanolamine naturally found in a variety of plant and animal food sources, as well as in mammalian tissues; here, it is naturally produced in response to inflammation and stress, to help regulate ache processes. For this reason, its supplementation has been extensively studied for its remarkable effect on the inflammatory cascade and soothing properties, offering a host of health benefits including relief from chronic ache signals.1,2
Since more and more people are turning to natural alternatives to manage their chronic ache symptoms, which can have a detrimental impact on daily life and overall well-being, the search for the perfect ally has already started.3 The aim? To find a natural remedy that not only helps regulate ache signals, but also teams up with conventional treatments, potentially minimizing their side effects.
Enter Cronilief™: an innovative nutraceutical compound that combines PEA with advanced Indena Phytosome™ technology, unlocking the molecule’s full health benefits to effectively manage chronic ache signals and promote relief.
Cronilief™ into action
What makes Cronilief™ so promising as a nutraceutical for chronic ache signals is PEA’s multi-factorial mechanism of action, able to target a plethora of molecules in the body that are involved in the ache signaling pathway.4
In particular, PEA has been shown to interact with various receptors, such as PPAR-α and GPR55, resulting in both a decreased production of inflammatory cytokines (TNF-α, interleukins 1β and 6) and a downregulation of enzymes involved in the inflammatory cascade (COX-2, iNOS). Due to these significant characteristics, PEA is effective in relieving ache signals.4,5
PEA can also act through the “entourage effect”: it can inhibit the enzyme Fatty Acids Amide Hydrolase (FAAH) that is known to catalyze anandamide (AEA), which can also produce analgesic-like and anti-inflammatory effects via its interactions with cannabinoid receptor signaling pathways.6,7
Furthermore, PEA helps modulate chronic ache signals by reducing mast cell degranulation, an inflammatory process that plays a role in pain pathophysiology and allergic reaction development.5
These promising benefits have also been evaluated in various clinical trials, which have found that PEA may be a useful, well tolerated aid for the management of ache symptoms.8
Find out how Cronilief™ is one step beyond
Cronilief™ is a uniquely promising nutraceutical because it provides a solution to one of PEA’s limits: its bioabsorption. Although found to be clinically well tolerated and effective in reducing ache signals, PEA is poorly soluble in water and aqueous environments due to its lipophilic nature, resulting in a low absorption rate.8,9
Here is where the advanced Indena Phytosome™ technology steps in: it enhances the bioabsorption of PEA without altering its structure and tolerability, ensuring food-grade quality.
Altogether, Cronilief™ is an innovative nutraceutical that helps tap into PEA’s full bioactive potential – effectively improving the management of chronic ache signals and symptoms.
Bibliography
1Ganley OH, et al. J. Lab. Clin. Med. 51:709–714. (1958).
2Petrosino S, et al. British journal of pharmacology. 174(11): 1349-1365. (2017).
3Zimmer Z, et al. PAIN. 163(9): 1740-1750. (2022).
4Lo Verme J. Mol. Pharmacol. (2005).
5Rankin L, et al. International Journal of Molecular Sciences. 21(21): 7942. (2020).
6Di Marzo V. Biochem J. (2001).
7Ambrosino P, et al. Br. J. Pharmacol. (2014).
8Artukoglu B, et al. Pain Physician. (2017).
9Beggiato S, et al. Frontiers in pharmacology. 10: 821. (2019).
CRONILIEF™ at a glance
Why choose Cronilief™?
01.
Is an innovative food-grade product.
02.
PEA provides significant relief for chronic ache signals (proven by in vitro, in vivo, and clinical studies).
03.
PEA has a pleiotropic effect on various signaling pathways.
04.
PEA interferes with inflammatory pathways, including physiological ones.
05.
PEA has been shown to be well tolerated and safe.
06.
Optimizes PEA’s bioabsorption profile thanks to the advanced Indena Phytosome™ technology.
Technical Data
Common Name
Palmitoylethanolamide Indena Phytosome™
Type
Plant source
HALAL Certified
Health benefit
Ache signaling
Patent & Trademark
Cronilief™ is a trademark of Indena S.p.A. The use of Indena’s trademarks is subject to Indena’s authorization.
Specifications
Cronilief™ is standardized to contain 40% mg of PEA
Recommended dose and use
300 mg, twice a day. Cronilief™ is a light brown powder for use in nutritional supplements.
Assay
≥35.0% ≤40.0% of palmitoylethanolamide by HPLC
Broad category
Chronic ache relief
These statements may not comply with your country’s laws and regulations or with Reg. EC n. 1924/2006 and have not been evaluated by the Food and Drug Administration. The products are not intended to diagnose, treat, cure or prevent any disease. Marketers of finished products containing this ingredient are responsible for ensuring compliance with the applicable legal framework.
