KEEP YOUR METABOLISM BALANCED, NATURALLY
Browse all Indena’s documents about products, events, company information and so much more.
Go to section
NUTRACEUTICALS
Berbevis®
Berberine - Indena Phytosome™
Scroll to see more
NEW SCIENTIFIC EVIDENCE
WHEN ONE DOSE IS ENOUGH
New clinical evidence has shown that a single daily administration of Berbevis® is effective in maintaining a balanced lipid metabolic profile and managing body parameters. This is a remarkable confirmation that our Berberine - Indena Phytosome™ plays a role in supporting a healthy body by influencing its composition.
While it is essential to adopt a low-calorie, low-cholesterol diet and engage in moderate exercise to make the kind of lifestyle changes necessary to modulate the availability of fatty tissue “building blocks”, support from Berbevis® can transform an attempt into “THE successful strategy” to achieve lipid and favorable body composition.
Discover the results
Overview
We’ve set the absolute advantage
For centuries, plants from the Berberis genus have been widely used in traditional Asian medicine for their health benefits; among them, a particular species – Berberis aristata – is also mentioned in the Ayurvedic Pharmacopoeia of India.2
From a scientific point of view, berberine is recognized as a natural bioactive alkaloid obtained from plants belonging to the Berberis genus, proven to favorably modulate blood profiles such as plasma lipids and glucose levels, therefore contributing to metabolic wellbeing.3
Finding a way to keep our metabolism balanced is one of our time’s main global health targets, as a springboard to fight multifactorial noncommunicable disorders such as metabolic syndrome, PCOS or type-II diabetes.3
This urgent need started the journey that led to Berbevis®, your natural ally for a healthy metabolism: an innovative berberine extract obtained from Berberis aristata with an optimized bioabsorption profile, thanks to the Phytosome® delivery system.4
Berbevis® into action
In recent years, berberine has received widespread attention due to its good potential for optimal metabolic wellbeing during our lifespan.
Its efficacy is linked to the berberine’s so-called “Cloud Effect”: its pleiotropic action that simultaneously affects both root causes (e.g. low-grade chronic inflammation, oxidative stress, gut microbiota modulation) and visible effects (e.g. insulin response) through the modulation of several cellular targets (e.g. AMPK, mitochondria, insulin-receptors, key metabolic enzymes).5
To confirm its multi-target potential, Berbevis® has been extensively studied in in vitro, in vivo and human studies where it showed to effectively support metabolic health: favorably modulating insulin response; improving the blood sugar profile, leveling both glycemia and insulin; optimizing the blood lipid profile; having a positive effect on body composition, and inducing the redistribution of adipose tissue.6,7
One of the most recent studies on Berbevis®, for example, has shown that it is possible to reshape the path of near-to-hyperlipidemic subjects with a single administration of Berbevis® a day, balancing their lipid profile and favorably affecting body composition.1
Furthermore, other studies highlighted its activity promoting hormonal balance and its positive effect on low-grade chronic inflammation.8
Find out how Berbevis®
is one step beyond
The unique strength of Berbevis® is directly connected to one of berberine’s main limits: bioavailability. The raw extract is, indeed, characterized by a poor oral bioavailability and bioabsorption profile.
The solution to this is the next-generation Indena Phytosome™ delivery system based on a new custom formulation – specifically designed according to the properties of berberine – with 3 innovative features. The first one is the use of pea proteins as carrier within the Indena Phytosome™ matrix; the second, the use of Berberis aristata raw extract, which is more soluble than pure berberinee.
Grape seed extract is the third term in the equation, serving as a powerful, natural antioxidant to protect the intestinal mucosa against the known gastrointestinal adverse effects of traditional berberine, optimizing its tolerability.9
The new custom Indena Phytosome™ makes Berbevis® a multi-target food-grade ingredient with optimized bioabsorption, marking a great improvement on the original berberine’s bioavailability (on molar basis level and with observed dose linearity).7
Things to Watch
Things to watch
Berbevis®
Keep your metabolism balanced, naturally
Are you curious to discover Berbevis® - Berberine Phytosome® - your natural ally for a healthy metabolism? In just a few minutes, you’ll hear why Berbevis® stands as a promising candidate for the management of a range of multifactorial disorders.
PRODUCTS / 24 Oct 24
4.28
See through science
Peer-reviewed science on Berbevis®
Here you can find more scientific evidence for your review.
ACCESS NOWBibliography
1Cesarone MR, et al. Minerva Gastroenterol (Torino).70(1):10-15. (2024).
2Imenshahidi M, et al. Phytother Res. 30(11):1745-1764. (2016).
3Kulkarni SK, et al. Eur J Pharmacol. 589(1-3):163-72. (2008).
4Yu F, et al. Eur J Pharm Biopharm. 103:136-148. (2016).
5Kong WJ, et al. Pharmacol Ther. 209:107496. (2020).
6Rondanelli M, et al. Nutrients 13.(2021).
7Riva, et al. Indena data on file.
8Li MF, et al. Evid Based Complement Alternat Med. 2018:2532935. (2018).
9Ma, Bing-Liang, et al. Scientific reports 6.1:1-11. (2016).
BERBEVIS® AT A GLANCE
Why choose Berbevis®?
01.
Promotes a healthy wellbeing, positively modulating blood sugar levels in a plethora of multifactorial disorders, such as type-II diabetes and PCOS (Polycystic Ovary Syndrome).
02.
Is the perfect ally to rebalance the lipid profile.
03.
Is useful for favorable body composition and fat/muscle ratio.
04.
Shows an optimized bioabsorption profile thanks to the new Indena Phytosome™ custom formulation.
05.
Has a pleiotropic effect on several pathways involved in regulating metabolism balance.
06.
Hampers the signs and symptoms of metabolic disorders.
07.
Supports hormonal balance.
08.
Tested in in vitro, in vivo and human studies.
09.
Well tolerated and safe, even for prolonged use.
Technical data
Common Name
Berberis aristata standardized extract phospholipids
Botanical Origin
Berberis aristata
Type
Extract
Plant source
Root
-
Health benefit
Blood glucose homeostasis, Hormonal control , Metabolism balance
Patent & Trademark
Berbevis is a trademark of Indena S.p.A. The use of Indena’s trademarks is subject to Indena’s authorization and to the acceptance of the terms and conditions set out in the Trademark Usage Guidelines downloadable HERE..
Specifications
Berbevis® is standardized to contain 28 – 34% of Berberine by HPLC
Recommended dose and use
2 x 550 mg/day
Assay
28 – 34% of Berberine by HPLC
Broad category
Healthy Metabolism, Multifactorial Disorders, Hormonal Balance
These statements may not comply with your country’s laws and regulations or with Reg. EC n. 1924/2006 and have not been evaluated by the Food and Drug Administration. The products are not intended to diagnose, treat, cure or prevent any disease. Marketers of finished products containing this ingredient are responsible for ensuring compliance with the applicable legal framework.
Berbevis® documents
