健全な炎症反応
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セクションに移動With Casperome®, the whole variety of boswellic acids reach multiple targets;
The exclusive Phytosome® formulation of Casperome® allows the optimized diffusion of ingredients since the first administration;
Benefits are measurable after only 3 days in joint challenges and 7 days in gut health;
The recommended 250 mg daily dosage provides the real effective daily intake of boswellia;
Casperome® is a good companion of Meriva® for the healthy inflammatory response because boswellic acids elicit a mechanism of action that is complimentary to the one of curcumin;
Casperome® is a good companion of Quercefit® during the allergy season because it supports the inflammatory response component of the discomforts, while quercetin supports the immunomodulatory aspect;
Casperome® is made through a highly controlled supply chain;
Casperome® is supported by a solid technical documentation package. Indena’s customer support is available to customers for any detail on product quality, safety, activity and clinical information.
Casperome® has been shown to:
• support the management of gut discomforts;
• support the management of airways discomforts during allergy season;
• support the management of joints discomforts, helpiung full functionality and recovery in sports.
Casperome® formulation maximizes the delivery of the whole bouquet of boswellic acids, that is the triterpenoic acids of Boswellia serrata endowed with healthy inflammatory support activity via backed-up mechanisms:
• inhibition of cathepsin G (catG), a protease enzyme which can regulate immune reaction and inflammatory response by modifying chemokines, cytokines, and cell surface receptors, and activate some lymphocytes;
• inhibition of cytokines involved in inflammatory process, such as TH1, t TNF-α and interleukins (IL-1β);
• inhibition of enzymes crucial for modulation of inflammatory response, such as microsomal prostaglandin E synthase (mPGES)-1, involved in prostaglandins synthesis;
• inhibition of the synthesis of 5-lipoxygenase (5-LO), enzyme involved in synthesis of leukotrienes.
• Casperome® is a botanical ingredient with unique composition and formulation:
- It contains not only KBA and AKBA, but the whole bouquet of boswellic acids
- It closely matches the composition profile of B. serrata resin
• Human tested formulation able to enhance and accelerate the delivery of terpenoic acids compared to unformulated extract
- Casperome® is the only ingredient on the market with a PK study on 6 boswellic acids;
- Boswellic acids are delivered, in average, 3 times more efficiently than with the unformulated extract;
- Peak concentrations of boswellic acids are reached faster than with the unformulated extract.
Casperome® is the only Boswellia extract with human studies on the management of airways discomforts during allergy season and on gut health.
参考文献目録
1. Riva A. et al, Phytomedicine 2016, 25, 1375-1382
2. Pellegrin L. et al., Eur Rev Med Pharmacol Sci. 2016, 20, 2695-2700
3. Belcaro, G. et al., Eur Rev Med Pharmacol Sci. 2017, 21, 2249-2254.
4. Riva A. et al, Minerva Gastroenterologica e Dietologica 2019, 65(1), 30-5
5. Ferrara, T. et al., Eur Rev Med Pharmacol Sci 2015, 20(19), 3757-3762.
6. Franceschi, F. et al., Eur Rev Med Pharmacol Sci 2016, 20(19), 4156-4161.
7. Fergalli, B., et al., Eur Rev Med Pharmacol Sci 2016, 20(19), 4726-4732.
ボスウェル酸で高度に標準化されており、生体吸収を最適化するためフィトソーム®送達システムを用いて処方されている。
カスペローム®由来のボスウェル酸の生体吸収は、血漿中濃度と組織中濃度の両方で大幅に最適化される。
薬物動態試験を含む、10件を超えるヒト試験によって裏付けられている。
筋骨格の健康、特に肘や腱の問題をサポートできる。
一般名
カスペローム®-ボスウェリアフィトソーム®
基原植物
Boswellia serrata Roxb. ex Colebr. - Resin
種類
エキス
植物部位
樹脂
健康上の効能
呼吸器の健康, 筋骨格系の健康, 腸の健康, 関節の健康
商標
CasperomeカスペロームはIndena S.p.Aの商標です。インデナ社の商標を使用するには、インデナ社の承認と、ここでダウンロード可能な商標使用ガイドラインに記載されている諸条件の受諾を条件とします。
規格
Standardized to contain ≥25% of triterpenoid acids
推奨用量および用法
1日250~500 mg。カスペローム® は黄色の粉末で、さまざまな栄養補助食品に使用することができます。
アッセイ
ボスウェル酸25.0%以上 (HPLC)
広義のカテゴリー
健全な炎症反応、関節と腸の健康
これらの記述は、お客様の国の法規制やReg. EC n.1924/2006に準拠していない可能性があり、米国食品医薬品局による評価を受けていません。本製品は、いかなる疾患の診断、治療、治癒または予防を目的としたものではありません。本成分を含有する最終製品の販売業者は、適用される法的枠組みの遵守を保証する責任を負っています。
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