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Quercefit®

Quercefit®

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PEER-REVIEWED SCIENCE ON QUERCEFIT®

Fatigue? The answer is Quercefit®

A double-blind, randomized, placebo-controlled clinical study recruited 78 individuals with fatigue to evaluate the positive effects of administering Quercefit® (500 mg/day) on self-reported fatigue levels, sleep quality, and physical performance after a 2-month period from the baseline visit. 

Data from the treatment group showed significant improvements in all parameters measured, including the FIS-40 scale (fatigue score), PSQI scale (sleep quality), and SPPB test (physical performance), compared to both the baseline and the placebo group (Figure 1).

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Figure 1: Variation of FIS-40, PSQI and SBBP in placebo group and treatment group vs baseline, after 2 months of treatment. *p<0.0001 vs placebo; ** p<0.001 vs placebo; ***p<0.001 vs placebo.

Is this the beginning of a natural approach?2

The administration of Quercefit® for a three-month period has been correlated with a favorable modulation of the body’s physiological response to symptomatic Covid-19 (Figures 2, 3).

This stems from the results of a single-center, prospective, randomized, controlled cohort study that enrolled a total of 120 healthcare workers (not vaccinated and taking all virus containment measures) randomized into two groups (60 subjects each), supplementing respectively with Quercefit® (250 mg twice a day) or a placebo.

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Figure 2: Survival without Covid-19 during follow-up time between groups.

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Figure 3: Conditions assessed by NEWS in subjects exposed to Covid-19.

Help from nature3,4

The administration of Quercefit® as diet supplementation showed positive effects in another study: of the 5 subjects who contracted Covid-19, there was only 1 out of the 60 in the quercetin Indena Phytosome group and 4 out of 60 in the control group. Complete clinical remission was recorded at 7 and 15 days in the supplementation and placebo groups, respectively.

These data were obtained during a prospective, randomized, controlled, open-label study in which 152 subjects were enrolled and randomized in two groups treated respectively with standard care or standard care plus Quercefit® (500 mg twice a day).3

A second clinical trial confirmed the benefits of diet supplementation with quercetin. The results showed that subjects who received Quercefit® (n= 21) had better outcomes compared to the ones receiving standard care.4

All data confirmed for Quercefit®5

These data were validated thanks to the completion of an initial clinical study now extended to 100 Sars-CoV-2-positive subjects that received standard care either alone or with Quercefit® as add-on supplementation (500 mg 3 times a day for the first week; 2 times a day for the second). The results confirmed that subjects who received standard care plus Quercefit® recovered faster and were in better health compared to the control group.

Indeed, 68% of the subjects who received quercetin supplementation recovered faster from the virus (within one week), compared to 24% in the control group (Figure 3). Moreover, individuals following the Quercefit® regimen had weaker symptoms and showed a better biomarker profile (reduction of LDH) within a week. These data are also complemented by the confirmation of the product’s good tolerability.5

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Figure 4: Subjects’ follow-up RT-PCR COVID-19 test results in the two groups.

Improvements in allergy-related discomforts and quality of life6

Repeated oral intake of a Quercefit®-containing supplement for 4 weeks has been shown to reduce allergy-related symptoms such as eye itching, sneezing, nasal discharge and sleep disorders compared to the placebo group (n=66).6

Moreover, the treated group also experienced improved quality of life, as reported in the chart below (Figure 5). 6

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Figure 5: Total score of the Japanese Rhino-conjunctivitis Quality of Life Questionnaire in the two groups, before starting supplementation (baseline), and 2 and 4 weeks later. Graphic representation of ref.1 table III.

Allergic conjunctivitis? Try Quercefit® as complementary treatment7

Confirming its beneficial role for ocular allergy-related disorders, a study performed on adults affected by allergic conjunctivitis showed that Quercefit® may potentially be the perfect natural aid to avoid clinical worsening. In particular, an analysis on 15 subjects after 15 days of supplementation (250 mg, twice a day) highlighted significant improvements in terms of Total Ocular Symptoms Score (TOSS) (Figure 6).7

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Figure 6: TOSS score before and after 15 days of Quercefit® supplementation.

Where it helps: allergy-prone subjects8

Quercefit® shows a potential promising effect during allergy season. A further study confirms that after 30 days, administration optimizes general wellbeing in allergy-prone subjects and modulates rhinitis, in addition to reducing the frequency of intermittent discomforts up to 50% during the day and up to 70% during the night.8

Prompt wellbeing restoration for injured eyes9

A series of 8 case studies have confirmed that Quercefit® can be the perfect ally for eye health, during topical antibiotic therapy on damaged ocular tissues (Figure 7).  

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Figure 7: Corneal condition following misuse of soft daily contact lenses, before (a) and after (b) supplementation.

直奔主题1

Quercefit®的槲皮素溶解度提高了 1倍,进而使 Quercefit®的生物利用度提高了 20倍,并且能够以较低的剂量使用,同时提供与富含蔬菜和水果的饮食水平一致的槲皮素摄入量。 根据一项针对 12名参与者(18-50岁)的试验,口服一剂普通的槲皮素(500毫克)、250毫克 Quercefit®和 500毫克 Quercefit®,Quercefit®组的血浆槲皮素水平更高。

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图 1:摄入普通槲皮素(白点)、Quercefit® 250 mg(灰点)和 Quercefit® 500 mg(黑点)后,槲皮素血浆浓度 (ng/ml)的时间变化。

与众不同之处:运动营养2

在对 48名非专业铁人三项运动员进行的一项试验中,Quercefit®显示出对训练和表现的积极影响。 Quercefit®给药组比未给药组跑得更快(-11.3% vs. -3.9%)。同样,Quercefit®可以改善跑步后的肌肉不适和痉挛以及运动后的恢复时间,并且还可以平衡氧化应激。

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图 2:Quercefit®给药组和未给药组中的血浆自由基 (PFR)单位。

有帮助的地方:易过敏的人群4

Quercefit®在过敏时代显示出潜在的保护作用。 Quercefit®给药30天后,可优化易过敏受试者的总体健康状况,并调节鼻炎评分。 30天后,Quercefit®组白天间歇性不适频率减少高达 50%,夜间间歇性不适频率减少高达 70%。

参考文献
1 Rondanelli M. et al.; Biomedicine & Pharmacotherapy 167 (2023): 115453.
2 Rondanelli M. et al.; Life (2022).
3 Di Pierro F. et al.; Int J Gen Med 14 (2021):2359.
4 Di Pierro F. et al.; Int J Gen Med 14 (2021):2807-2816.
5 Di Pierro F. er al; Frontiers in Pharmacology (2023).
6 Yamada, S. et al. European review for medical and pharmacological sciences (2022) 4331–4345.
7 Mazzolani et al.; Austin of allergy (2022).
8 Cesarone, M. R., et al.; Minerva medica (2019).
9 Mazzolani et al.; International Journal of Case Studies in Clinical Research (2022); Volume 6 Issue 3: 10-19.
10 Riva A. et al.; Eur J Drug Metab Pharmacokinet (2018).
11 Riva A. et al.; Minerva Medica (2018); 109(4):285-9.

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