Sabalselect®
Browse all Indena’s documents about products, events, company information and so much more.
Go to section
See through science
Sabalselect®
Scroll to see more
Peer-reviewed science on Sabalselect®
For a healthy prostate2
Serenoa repens extract appears to be effective and well-tolerated in subject with prostatic stress.
The effect of a 160 mg oral dose of S. repens extract, twice a day, has been studied in a 3-months trial on 505 subjects with prostatic stress. Traditional parameters for quantifying prostate health, such as quality of life score, urinary flow rates, residual urinary volume and prostate size, were significantly optimized after only 45 days of administration. After 3 months of administration, the majority of participants considered the therapy effective.
Figure 1: Evolution of several parameters related to prostatic function after S. repens extract administration at different times (day 0, day 45, day 90).
1 year efficacy
in humans3
S. repens extract is a safe and good support for subjects with prostatic stress also in its double dosage form of 320 mg. After a 1-year administration in 132 subjects comparing the efficacy and safety of 2 dosage forms (160 mg and 320 mg), both dosage forms induced a significant positive effect of quality of life score, prostatic volume, maximum flow rate, mean flow rate and residual urinary volume. No significant differences were found between the 2 dosage forms.
Figure 2: Evolution of prostatic volume (mm3), flow rates (mL/s) and residual volume (mL) according to time and S. repens extract administration dosage.
BIBLIOGRAPHY
1Duke J.A., “CRC - Handbook of Medicinal Herbs” 443 (1991).
2Braeckman J., Curr. Ther. Res. 55, 776 (1994).
3Braeckman J., Bruhwyler J., Vandekerchove K., Géczy J., Phytother. Res. 11, 558 (1997).
4Indena S.p.A., Internal Report 41/05/LRA-00.
5Hagenlocher M., Romalo G., Schweikert H.U., Akt. Urol. 24, 146 (1993).
6Bayne C.W., Grant E.S., Chapman K., Habib F.K., J. Urol. 157, 194 (1997).
7Breu W., Hagenlocher M., Redl K., Tittel G., Stadler F.,Wagner H., Arzneim. Forsch. 42, 547, (1992).
8Paubert-Braquet M., Mencia Huerta J.M., Cousse H., Braquet P.,Prostaglandins, Leukotrienes and Essential Fatty Acids 57, 299 (1997).
9Paubert-Braquet M., Cousse H., Raynaud J.P., Mencia Huerta J.M., Braquet P., Eur. Urol. 33, 340 (1998).
10Wilt T., Ishani A., Mac Donald R., The Cochrane Library, Issue 2 (2004).
11Odenthal K.P., Phytother. Res. 10, S141 (1996).
12Di Silverio F., D’ Eramo G., Lubrano C., Flammia G.P., Sciarra A., Palma E., Caponera M., Sciarra F., Eur. Urol. 21, 309 (1992).
