Ubiqsome^®

In a human study conducted on healthy athletes over 50 years old performing a complete training session in a climatic chamber, Ubiqsome^® significantly (p<0,05) optimized CoQ10 levels in muscles by +36% (Figure 2).

Moreover, it improved the total antioxidant capacity (TAC) and favorably controlled biomarkers of oxidative stress and inflammation.

Ubiqsome^®, with its enhanced CoQ10 antioxidant activity, supports muscle function under physical and athletic stress, and helps preserve muscle health during prolonged therapies such as statins or GLP-1 agonists.

A double blind randomized, placebo-controlled clinical study enrolled 60 subjects experiencing statin-associated asthenia, to assess the effects on muscle strength of dietary supplementation with Ubiqsome^®.

At each time-step for 8 weeks, the treated group and the placebo group were administered with 3 physical tests: handgrip test (HGT), 1-minute sit-to-stand repetition (STS), 2-minute step test (2MST). Subjects’ asthenia levels were measured using the Visual Analogue Scale (VAS).

At the end of the study, people following the Ubiqsome^® supplementation regimen (150 mg of Ubiqsome^® twice a day) reduced by half the asthenia sore, while experiencing an amelioration in HGT (+29.8 ± 3.6%), 1-min STS repetitions (+36.4 ± 3.9%), and 2MST (11.1 ± 1.8%) (p <0,05 vs baseline and vs placebo) (Fig. 3).

Only if properly delivered, oral CoQ10 can support skin cellular energy from within: Ubiqsome^® is the right example.

In an ex-vivo study vs unformulated coenzyme Q10, Ubiqsome^® demonstrated significantly higher absorption efficiency in human dermal cells.

Low-density lipoproteins (LDL) were taken from the plasma of subjects who received either the Indena Phytosome^TM formulation (Ubiqsome^®) or the crystalline form of CoQ10, and were incubated with cell line. 

The Indena Phytosome^TM delivery system demonstrated superior bioabsorption and cellular uptake. This resulted in CoQ10 being delivered to human dermal fibroblasts more efficiently - 9x vs baseline - and 2x vs traditional CoQ10.

Endothelial function is an important early marker for cardiovascular health, reflecting the ability of the endothelial layer to fight early pro-atherosclerosis conditions. 
Since endothelial dysfunction is primarily driven by oxidative stress (like Reactive oxygen species - ROS and NO deficiency), the antioxidant potential of Ubiqsome^® is a valuable ally to maintain the endothelium in good health.

A scientific evidence on healthy young people has confirmed this hypothesis, showing the optimization of endothelial function (+7% p<0,05) both in acute and chronic settings after the supplementation of Ubiqsome^® (Fig. 5).

An in-vitro evaluation on muscular and intestinal cell lines has confirmed that macropinocytosis could be the key mechanism for the internalization of Ubiqsome^® at cellular level, since the use of a macropinocytosis inhibitor drastically reduced CoQ10 cellular content.

The same study also confirmed that the Indena Phytosome^TM delivery system enhances intracellular concentration of CoQ10, compared to the coenzyme alone (Fig. 6).

This confirms that the action starts from the cells.