Thanks to Casperome^® – Indena’s Boswellia Phytosome^® – keeping gut healthy is natural and safe

Milan, 27 July 2022 – In the summer, travelling abroad is the perfect chance to taste new food, but new culinary experiences may often put at risk people’s gut health. Gut health already is a relevant issue all over the world. Just to give an idea, in the USA from 60 to 70 million people are affected by all digestive diseases¹, over 1 million residents in the USA and 2.5 million in Europe are estimated to have Inflammatory Bowel Disease² and Irritable Bowel Syndrome occurs in up to 15% of the United States population.³

From nature, a valid support may come from Boswellia serrata, and among Indena’s innovative botanical extracts there is CASPEROME^®: a whole natural, tested, standardized extract of Boswellia serrata enriched in the whole bouquet of terpenoid acids. Its composition includes 11 relevant boswellic acids, and closely matches the profile of the natural resin. Moreover, CASPEROME^® is formulated with the Indena’s proprietary Phytosome^® delivery system, which makes natural ingredients more bioavailable and effective. CASPEROME^® is a unique and tested formulation, able to enhance and optimize the delivery of terpenoic acids compared to unformulated extract.⁴

Indena’s CASPEROME^® has been proven as a natural support for gut health thanks to three human studies. Two of them showed that CASPEROME^® supports healthy inflammatory response, maintaining physiological intestinal mobility, thus contrasting other unpleasant conditions such as bloating. A third study evaluated the effects of CASPEROME^® usage over 6 months, confirming its efficacy, safety, benefits and excellent tolerability.

More recently, new clinical evidence⁵ showed the benefit potential of CASPEROME® being effective in preserving normal intestinal motility when in the hot season probable embarrassing gastrointestinal condition may occur: acute diarrhea.

The two most common causes of acute diarrhea are gastrointestinal infections or food poisoning, and viruses represent the most frequent etiologic factor. In the United States, 48 million people suffer every year from acute diarrhea due to acute food poisoning, and 2.5 million people die from acute diarrheal disease worldwide. CASPEROME® counteracts such embarrassing conditions.

“The randomized, double-blind, placebo-controlled trial showed that our CASPEROME^® can normalize intestinal motility, thus counteracting the formation of loose and watery stools: in conditions when the risk of experiencing acute diarrhea may be higher, it significantly reduces the number of stools and duration of motility unbalance, along with associated secondary conditions – says Antonella Riva, Indena’s Head of Product Innovation and Development -.  Boswellia serrata extract can act as a Ca²⁺ channels modulator and CASPEROME^® optimizes its delivery to the target organ: intestinal smooth muscles. Moreover, no side effects have been observed: CASPEROME^® counteracts motility unbalance, without slowing down the transit rate, and this is a major advantage since other agents induce constipation”.

Another important result from Indena’s research activity, always aimed to find more and more innovative solutions for human wellbeing. 


[1] https://www.niddk.nih.gov/health-information/health-statistics/digestive-diseases
[2] Eisenstein M. Nature 540, S98-S99
[3] https://www.hopkinsmedicine.org/health/conditions-and-diseases/irritable-bowel-syndrome-ibs https://www.hopkinsmedicine.org/health/conditions-and-diseases/irritable-bowel-syndrome-ibs
[4] Riva A. et al, Phytomedicine 2016, 25, 1375-1382
[5] Giacosa, A.; Riva, A.; Petrangolini, G.; Allegrini, P.; Fazia, T.; Bernardinelli, L.; Peroni, G.; Rondanelli, M. in Nutrients 2022, 14, 1858.