Anthocran® Indena Phytosome™
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Anthocran® Indena Phytosome™
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Peer-reviewed science on Anthocran® Indena Phytosome™
Anthocran® Indena Phytosome™ is the result of continuous research and development on cranberry extracts, which started with the identification of new biologically active metabolites and has culminated with human studies on urinary tract health. 1,2,3
The ingredient fingerprint
New HPLC analysis has allowed a complete profiling of the bioactive components in Anthocran® Indena Phytosome™, including PACs (proanthocyanidins) but also other naturally occurring polyphenols typically found in cranberry juice. Final results showed that Anthocran® Indena Phytosome™ maintains the same phytochemical profile of natural cranberries, thanks to its unique and careful industrial manufacturing processes.1
Moreover, a pharmacokinetic study conducted with an innovative method has allowed researchers to identify 42 urine metabolites, and provide new data to understand the protective activity of cranberry extracts for the urinary tract. In particular, valeric acids and valerolactons – well known PAC metabolites – were identified for the first time in human urines after cranberry intake.2
Candida albicans and and urinary tract management
An ex-vivo study on human urines (with 13 healthy female volunteers) compared the effect of unformulated cranberry extract (unitary PACs dose = 36 mg) to Anthocran® Indena Phytosome™ (unitary PACs dose = 9 mg) on Candida albicans proliferation in the urinary tract. Results showed that the new formulation matches the performance of the standard extract even at its lower concentration, thanks to the Indena Phytosome™ strategy that optimizes the absorption of phytoactive compounds and their delivery to target tissues (Figure 1).2
Figure 1: Unformulated extract vs Anthocran® Indena Phytosome™ activity on Candida albicans at different timesteps.2
Urinary tract protection: a human study
An important study was conducted on 64 subjects prone to UTIs in the post-operative period after undergoing non-complicated surgery requiring catheterization. Its goal was to verify the actual benefit of the add-on supplementation with Anthocran® Indena Phytosome™ (120 or 240 mg/die) compared to standard management. Subjects were divided into 4 groups, which were assigned different supplementations for 4 weeks and then monitored for 3 months of follow-up.3
The subjects belonging to Anthocran® Indena Phytosome™ groups experienced lower rates of urinary issues, measured with a validated VAS score. Furthermore, after 4 weeks no blood or traces of bacterial contamination were found in the corresponding samples, achieving the goal of zero total re-occurrence vs 17% and 18% in the two control groups.3
Table 1: Efficacy and safety of Anthocran® Indena Phytosome™ vs SM.3
BIBLIOGRAPHY
1Indena internal data
2G.Baron et al; Biochemical Pharmacology, 173 113726, (2020)
3R.Cotellese et al; Journal of Dietary Supplements, E-pub (2021)
